Table 1

Demographic characteristics, neurophysiological assessments, and sensory phenotype classification of study cohorts

RespondersNonrespondersP
n1415
Age (years)58.4 (11.1)55.8 (10.6)0.45
Male sex (n, %)10, 71.47, 46.70.36*
Type of diabetes (type 1/2) (n, %)5, 35.74, 26.70.70*
Duration of diabetes (years)18.0 (13.5)14.2 (10.1)0.19
Duration of pain (years)8.92 (7.2)7.46 (8.1)0.85
BMI (kg/m2)33.9 (9.2)30.9 (5.8)0.32
HbA1c (mmol/mol)68.8 (16.1)70.3 (23.5)0.91
HbA1c (%)8.4 (1.5)8.6 (2.1)0.91
NTSS-6 score15.7 (3.3)14.7 (5.0)0.61
TCNS32.5 (10.6)25.6 (14.4)0.25
Sural
 Conduction velocity (m/s)36.2 (3.3)30.6 (15.4)0.52
 Amplitude (mAmp)2.8 (2.9)3.4 (6.3)0.77
Common peroneal nerve
 Conduction velocity (m/s)36.7 (6.2)41.2 (9.9)0.27
 Amplitude (mAmp)1.8 (1.6)1.2 (1.8)0.43
 Distal latency (ms)4.5 (3.0)5.1 (2.9)0.60
Pain phenotype (n, %)
 IR nociceptor8, 57.22, 13.30.02*
 NIR nociceptor6, 42.913, 86.7
Medications (n)
 Pregabalin761.00*
 Duloxetine630.37*
 Amitriptyline111.00*
 Opiates750.65*
 Other020.47*
  • Data are mean (SD) unless otherwise indicated.

  • Statistically significant results (i.e., P < 0.05) appear in boldface type.

  • * P values for χ2 test.