Table 1

Characteristics of T1D participants by HLA-DQB1*06:02 status

DQB1*06:02+ (n = 50)DQB1*06:02 (n = 2,759)P value
Age at diagnosis, years (mean ± SD)10.8 ± 6.012.5 ± 8.70.069
Sex (% female)52 (n = 26)46 (n = 1,266)0.395
Race/ethnicity (%)0.540
 White86 (n = 43)80 (n = 2,213)
 Hispanic6 (n = 3)5 (n = 142)
 Other6 (n = 3)8 (n = 218)
 Unknown2 (n = 1)7 (n = 186)
Islet autoantibody status (%)
 GADA55 (27/49)52 (1,399/2,676)0.773
 IA-2A39 (19/49)60 (1,587/2,663)0.005
 IAA*35 (13/37)34 (479/1,398)1.00
 ZnT8A51 (18/35)62 (553/898)0.289
Number of islet autoantibodies (%)**0.009
 0 Ab30 (14/47)14 (247/1,827)0.004
 1 Ab19 (9/47)26 (474/1,827)0.398
 2 Ab21 (10/47)33 (607/1,827)0.115
 ≥3 Ab30 (14/47)27 (499/1,827)0.741
  • Ab, autoantibodies.

  • * IAA positive values were excluded from analysis if measured >21 days after T1D diagnosis.

  • ** Includes samples for which at least three islet autoantibodies were measured; overall P value is reported, followed by those for each category.