Table 2

Overview of HNF1A mutations, treatment, and diabetes status

SubjectMutation chromosome 12TreatmentDiabetes status
HNF1A-1Cys241GlyGlimepirideDiabetes
HNF1A-2IVSnt-2 a->gDietNo diabetes
HNF1A-3c.1623+1 g->tGlimepiride + linagliptinDiabetes
HNF1A-4Pro291fsinsCGlimepiride + liraglutideDiabetes
HNF1A-5Ala559fsinsALinagliptinDiabetes
HNF1A-6Deletion (exon2–10)GlimepirideDiabetes
HNF1A-7Pro291fsinsCRepaglinide + metforminDiabetes
HNF1A-8Pro291fsinsCGlimepirideDiabetes
HNF1A-9Pro379fsdelCTDietNo diabetes
HNF1A-10Glu234TermDietDiabetes*
  • “Diabetes” is defined as one measurement of HbA1c ≥48 mmol/mol at any time.

  • * Patient diagnosed with gestational diabetes mellitus during two pregnancies verified with oral glucose tolerance tests.