Table 3

Presence of selected DAAs among SEARCH participants with physician-diagnosed T1D from the 2002, 2005, and 2008 incident cohorts who completed a SEARCH baseline study visit and had DAAs measured: the SEARCH for Diabetes in Youth Study

Incidence Year
200220052008P value*P value for trend
n316324469
Age at visit (years)11.1 (4.0)11.1 (4.0)10.5 (44)0.050.02
T1D duration (months)13.0 (7.0)7.8 (5.2)8.2 (5.5)<0.0001<0.0001
DAA+ status
 GAD65+186 (58.9)184 (56.8)288 (61.4)0.420.53
 IA-2A+224 (70.9)230 (71.0)351 (74.8)0.360.25
 Either DAA+267 (84.5)278 (85.8)413 (88.1)0.340.16
DAA+ by age category (years)
 0–4 years20/22 (90.9)21/28 (75.0)52/61 (85.2)0.290.62
 5–9 years89/102 (87.3)85/98 (86.7)134/152 (88.2)0.940.85
 10–14 years108/131 (82.4)122/141 (86.5)152/174 (87.4)0.450.21
 ≥15 years50/61 (82.0)50/57 (87.7)75/82 (91.5)0.240.09
DAA+ by sex
 Female121/139 (87.1)128/145 (88.3)183/204 (89.7)0.750.46
 Male146/177 (82.5)150/179 (83.8)230/265 (86.8)0.430.23
  • Data are mean (SD) or n (%) unless otherwise indicated. IA-2A, IA-2 antibodies.

  • *P values for continuous variables were fit by using a general linear model with time period treated as a class variable. P values for categorical variables are based on χ2 test.

  • P values for continuous variables were fit using a general linear model with time period treated as a continuous variable. P values for categorical variables were tested using the Cochran-Armitage test for trend.

  • ‡Data are number positive/total tested (%).