Table 2

Effect of intensive glycemic control on the risk of developing new QT prolongation in ACCORD participants

Treatment armParticipantsEvents (n)Event rate (% per year)HR (95% CI)P
Framingham QTc formula (n = 9,886)0.95 (0.81–1.11)0.53
 Intensive glycemic control4,9293081.27
 Standard glycemic control4,9573261.33
Hodges QTc formula (n = 9,795)0.88 (0.77–1.01)0.07
 Intensive glycemic control4,8783811.59
 Standard glycemic control4,9174371.80
Bazett QTc formula (n = 9,448)0.87 (0.75–1.01)0.07
 Intensive glycemic control4,7403301.43
 Standard glycemic control4,7083821.63
  • The numbers of study participants and events (incident QT prolongation) and HRs from the Cox models are provided for each of three QT heart rate correction formulas. The number of participants differs between analyses because different numbers of participants met criteria for QT prolongation at baseline (which was an exclusion criteria) depending on which heart rate correction formula was used.