Broad characteristics of LADA*
| • Age >30 years** |
| • Family/personal history of autoimmunity |
| • Reduced frequency of metabolic syndrome compared with T2D—lower HOMA, lower BMI, lower blood pressure, and normal HDL compared with T2D |
| • No disease-specific difference in cardiovascular outcomes between these patients and those with T2D |
| • C-peptide levels decrease more slowly than in T1D |
| • Positivity for GADA as the most sensitive marker; other autoantibodies less frequent (ICA, IA-2A, ZnT8A, and tetraspanin 7 autoantibodies) |
| • Non–insulin requiring at onset of diabetes |
* None of these features categorically define LADA.
** Limited data on older patients with higher probability of T1D in younger patients.