Table 3

Determinants of RO2:GFR in adolescents with T1D

VariablesWhole-kidney RO2:GFR (ms/mL/min)Cortex RO2:GFR (ms/mL/min)Medullary RO2:GFR (ms/mL/min)
Crude valuesAdjusted P valueaCrude valuesAdjusted P valueaCrude valuesAdjusted P valuea
rP valuerP valuerP value
RPF (mL/min)−0.520.00090.004−0.450.0050.01−0.62<0.00010.003
Log UACR (mg/g)−0.310.030.01−0.260.070.040.240.100.06
MAP (mmHg)−0.350.020.06−0.290.040.048−0.390.0050.01
Heart rate (bpm)0.100.510.690.070.650.700.120.420.51
Hematocrit (%)−0.330.020.11−0.270.060.11−0.370.0090.048
Lactate (mg/dL)−0.340.020.004−0.380.0070.0009−0.350.010.002
KIM-1 (pg/mL)−0.270.060.04−0.260.070.04−0.260.070.047
Fat mass by DXA (kg)−0.330.020.01−0.290.0490.02−0.340.020.003
Waist circumference (cm)−0.350.010.03−0.280.050.07−0.390.0060.01
Length of diabetes (years)−0.140.330.58−0.190.190.33−0.100.510.87
HbA1c (%)0.040.790.98−0.070.610.51−0.040.770.54
M/I (per kg)0.180.230.220.220.140.130.310.030.02
M/I (per FFM)0.150.330.370.190.200.220.290.0490.054
eIS0.300.040.13b0.270.070.09b0.390.0060.03b
  • a Adjusted for age, sex, and HbA1c.

  • b Adjusted for age and sex, as HbA1c is part of eIS equation.