Results of genotype risk score analysis of the 11 “lipodystrophy-like” variants
| Category/trait | Unit | Per-allele β | 95% CI | P | N |
|---|---|---|---|---|---|
| Nondisease metabolic traits of monogenic IR | |||||
| SHBG (BMI adjusted) | Natural log | −0.010 | −0.012, −0.008 | 9 × 10−13 | 21,000 |
| HDL-C | SD | −0.020 | −0.024, −0.016 | 7 × 10−37 | 99,900 |
| Adiponectin (BMI adjusted) | log | −0.015 | −0.017, −0.013 | 2 × 10−26 | 29,346 |
| BMI | SD | −0.008 | −0.012, −0.004 | 7 × 10−8 | 123,865 |
| VATSAT ratio | z-score | 0.015 | 0.009, 0.021 | 6 × 10−7 | 10,557 |
| CT-measured hepatic steatosis | SD | 0.021 | 0.009, 0.033 | 3 × 10−4 | 7,176 |
| ALT | log10 | 0.002 | 0.001, 0.003 | 3 × 10−5 | 55,474 |
| Triglyceride | SD | 0.018 | 0.014, 0.022 | 4 × 10−29 | 96,598 |
| Metabolic disease and disease-related outcomes | |||||
| T2D | OR | 1.043 | 1.031, 1.055 | 5 × 10−13 | 12,171 vs. 56,862 |
| CAD | OR | 1.013 | 1.007, 1.019 | 1 × 10−5 | 40,365 vs. 63,714 |
| Systolic blood pressure (BMI adjusted) | mmHg | 0.135 | 0.072, 0.198 | 2 × 10−5 | 69,828 |
| Diastolic blood pressure (BMI adjusted) | mmHg | 0.075 | 0.036, 0.114 | 2 × 10−4 | 69,816 |
| cIMT | log | 0.000 | −0.002, 0.002 | 0.70 | 31,210 |
| Carotid plaques | OR | 1.005 | 0.991, 1.019 | 0.50 | 25,179 |
The 8 nondisease metabolic traits were used to select the 11 variants, so associations are not independent of the clustering process. The metabolic disease outcomes were not used in the clustering process and so represent independent tests. VATSAT, visceral-to-subcutaneous adipose tissue. P values ≤ 0.001 are in bold.