Table 5

Associations between genetically predicted PCOS and risk of type 2 diabetes, CHD, and stroke with use of MR-Egger and weighted median methods

TraitMR-EggerWeighted median
OR (95% CI)PInterceptPInterOR (95% CI)P
Diabetes in Asian (all)0.96 (0.90–1.03)0.290.0050.580.99 (0.96–1.02)0.42
 Female0.96 (0.88–1.04)0.290.010.440.99 (0.94–1.03)0.53
 Male0.99 (0.90–1.09)0.83−0.0010.940.98 (0.93–1.02)0.34
Diabetes in European (all)1.00 (0.81–1.24)1.00−0.0040.750.95 (0.91–1.01)0.08
 Female0.97 (0.70–1.35)0.87−0.0030.880.88 (0.82–0.96)0.003
 Male1.02 (0.82–1.25)0.88−0.0050.730.97 (0.91–1.04)0.40
CHD0.91 (0.77–1.06)0.240.010.240.99 (0.95–1.04)0.76
 Any stroke1.06 (0.87–1.29)0.58−0.010.431.00 (0.94–1.07)0.90
  Any ischemic stroke1.04 (0.83–1.30)0.73−0.010.590.99 (0.92–1.06)0.72
   Large artery stroke1.02 (0.60–1.74)0.95−0.020.600.91 (0.77–1.08)0.29
   Cardioembolic stroke1.07 (0.69–1.66)0.77−0.020.500.94 (0.82–1.08)0.38
   Small vessel stroke0.88 (0.48–1.62)0.690.030.481.09 (0.92–1.29)0.33
  • PInter, intercept P value.