Table 1

PCOS SNPs used to construct the main instrument variable in Europeans

Chr:position	SNP	Effect allele	Other allele	EAF	β	SE	Nearest gene	P	F statistic
2:43561780	rs7563201	A	G	0.451	−0.108	0.017	THADA	3.68E−10	39.50
2:213391766	rs2178575	A	G	0.151	0.166	0.022	ERBB4	3.34E−14	57.66
5:131813204	rs13164856	T	C	0.729	0.124	0.019	IRF1/RAD50	1.45E−10	40.95
8:11623889	rs804279	A	T	0.262	0.128	0.018	GATA4/NEIL2	3.76E−12	48.09
9:5440589	rs10739076	A	C	0.308	0.110	0.020	PLGRKT	2.51E−08	31.01
9:97723266	rs7864171	A	G	0.428	−0.093	0.017	C9orf3	2.95E−08	30.84
9:126619233	rs9696009	A	G	0.068	0.202	0.031	DENND1A	7.96E−11	42.19
11:30226356	rs11031005	T	C	0.854	−0.159	0.022	ARL14EP/FSHB	8.66E−13	51.03
11:102043240	rs11225154	A	G	0.094	0.179	0.027	YAP1	5.44E−11	43.16
11:113949232	rs1784692	T	C	0.824	0.144	0.023	ZBTB16	1.88E−10	40.49
12:56477694	rs2271194	A	T	0.416	0.097	0.017	ERBB3/RAB5B	4.57E−09	34.22
12:75941042	rs1795379	T	C	0.240	−0.117	0.020	KRR1	1.81E−09	36.25
16:52375777	rs8043701	A	T	0.815	−0.127	0.021	TOX3	9.61E−10	37.46
2:49247832	rs2349415	T	C	0.343	0.076	0.017	FSHR	9.59E−06	19.65