Table 2

Genome-wide significant findings for youth-onset T2D

SNPChromosomePositionClosest geneTypeEffect alleleNon-effect alleleOR vs. adult control subjectsP value vs. adult control subjectsOR in adults (20)P value in adults (20)OR vs. youth control subjectsP value vs. youth control subjects
rs790314610114758349TCF7L2IntronTC1.588.0 × 10−201.375.8 × 10−4471.240.00091
rs729829881857802714MC4RIntronAG1.534.4 × 10−141.057.6 × 10−131.200.012
rs2008937881012283161CDC123IntronTTAGTA1.321.1 × 10−121.091.5 × 10−321.020.49
rs2237892112839751KCNQ1IntronCT1.594.8 × 10−111.126.0 × 10−321.250.13
rs9375891193185537636IGF2BP2InsertionGTG1.343.1 × 10−91.149.0 × 10−361.080.52
rs10992863996445803PHF2IntergenicGA1.233.2 × 10−8Novel for T2D*Novel for T2D*1.160.087
rs113748381176953155SLC16A11IntergenicAG1.044.1 × 10−81.29 (25)5.5 × 10−12 (25)1.360.16
  • A total of 3,006 youth case subjects with T2D were compared with 6,061 adult or 856 youth control subjects. Association tests were adjusted for age, sex, and genetic relationship matrix.

  • * P value for association with T2D in adults = 8.3 × 10−3 (Type 2 Diabetes Knowledge Portal, https://t2d.hugeamp.org/variant.html?variant=rs10992863) (20).