Table 2

Potencies of S02-GIP-T4 and [Ga]S02-GIP-T4 at the GIPR from human, rat, and NHP in transfected HEK293 cells compared with GIP (1–42)

HumanRatNHP
PeptideEC50 GIPR (pmol/L)EC50 GLP-1R (pmol/L)EC50 GCGR (pmol/L)EC50 GIPR (pmol/L)EC50 GLP-1R (pmol/L)EC50 GCGR (pmol/L)EC50 GIPR (pmol/L)EC50 GLP-1R (pmol/L)EC50 GCGR (pmol/L)
 GIP (1–42)0.48>10,000>10,0000.81>10,000>10,0000.42>10,000>10,000
 S02-GIP-T41.13>10,000>10,0004.37>10,000>10,0002.65>10,000>10,000
 [Ga]S02- GIP-T41.09>10,000>10,0002.63>10,000>10,0001.94>10,000>10,000