Table 3

Genome-wide significant findings for subjects with youth-onset T2D vs. adult control subjects with and without adjustment for BMI

SNPChromosomePositionGeneTypeEffect alleleNon-effect alleleORP valueBMI-adjusted ORBMI-adjusted P value
rs790314610114758349TCF7L2IntronTC1.523.5 × 10−111.592.0 × 10−11
rs729829881857802714MC4RIntronAG1.552.2 × 10−91.452.9 × 10−6
rs2008937881012283161CDC123IntronTTAGTA1.351.2 × 10−71.407.6 × 10−8
rs2237892112839751KCNQ1IntronCT1.613.9 × 10−61.705.4 × 10−6
rs109928639185537636PHF2InsertionGA1.334.0 × 10−61.251.2 × 10−4
rs937589119396445803IGF2BP2IntergenicGTG1.324.7 × 10−51.372.5 × 10−5
rs113748381176953155SLC16A11IntergenicAG0.994.1 × 10−30.923.6 × 10−2
  • Association tests for 898 case subjects with youth-onset T2D in whom BMI information was available were adjusted for sex and genetic relationship matrix and compared before and after BMI z-score adjustment.