Table 2

GPA test parameters

ABCA1Low HDL-C
HomozygousHeterozygousControl subjectsCase subjectsControl subjects
n = 3n = 8n = 8n = 9n = 9
AIRarg (μU/mL)62 ± 32a33 ± 828 ± 758 ± 10*27 ± 6
AIRpot (µU/mL)350 ± 228a195 ± 33*122 ± 20278 ± 45134 ± 14
AIRmax (µU/mL)426 ± 153*219 ± 30*173 ± 34304 ± 66143 ± 20
ACRarg (ng/mL)3.47 ± 0.86*2.03 ± 0.36*1.43 ± 0.263.07 ± 0.29*1.64 ± 0.25
ACRpot (ng/mL)14.17 ± 6.24a8.31 ± 1.70*6.30 ± 0.979.70 ± 1.065.24 ± 0.52
ACRmax (ng/mL)14.08 ± 6.01*8.39 ± 1.16*5.77 ± 0.5510.45 ± 1.66*5.60 ± 0.65
M (mg/kg/min)9.8 ± 0.19.6 ± 0.59.4 ± 0.78.7 ± 0.410.3 ± 1.0
I (µU/mL)52 ± 2545 ± 1128 ± 450 ± 1034 ± 6
M/I (mg/kg per min/µU/mL)0.30 ± 0.120.29 ± 0.050.36 ± 0.030.22 ± 0.030.37 ± 0.06
DI (mg/kg/min) 11.0 ± 1.89.0 ± 2.69.7 ± 2.311.0 ± 1.510.4 ± 3.6
  • Data are means ± SE.

  • ACRarg, acute C-peptide response to arginine under fasting conditions; ACRmax, acute C-peptide response to arginine under ∼340 mg/dL glucose clamp conditions; ACRpot, acute C-peptide response to arginine under ∼230 mg/dL glucose clamp conditions.

  • aP ≤ 0.1 case subjects vs. control subjects.

  • *P < 0.05 case subjects vs. control subjects.

  • P < 0.01 case subjects vs. control subjects.